A rapidly expanding Biotech client of mine is currently looking for a Lead Automation Engineer to join them on a permanent basis at their site in the Southwest of England.
- Lead the automation effort within the T cell PD team acting as a central point of contact to provide strong links between PD, Manufacturing and Quality.
- Act as an interface between the biology of the process and the engineering requirements of the automation strategy.
- Provide bioengineering input to the development team, including tools to evaluate the COGS and capacity / cycle time benefits of various process and automation improvement options.
- Project management working with a matrix team of individuals to progress automation strategies from Development into Manufacturing.
- Generate and maintain an understanding of the cell therapy automation landscape.
- In collaboration with the scientific technical leads from the T cell team, provide technical review of experimental designs, results, conclusions and the automation development plans for automation within the T cell PD team Development.
- In conjunction with the T cell PD Group Leader, Head of Process Development and other parties from Quality and Manufacturing contribute to the strategic direction for T cell process automation to decrease COGS, increase manufacturing capacity and increase assurance of product quality.
- Provide assistance during the tech transfer of fully developed process automation technology to the Manufacturing team for implementation and validation within GMP production.
- Manage any outsourced development activities for T cell process automation with subcontractors, collaborating with the scientific and technical leads as appropriate.
- BSc or higher qualification in relevant area; Biology, Engineering or, and ideally, Biochemical Engineering.
- Significant post-academic, industrial experience working at the interface of biology and engineering is a must.
- Experience with, or at least the awareness of, the particular challenges for autologous cell therapy process industrialisation is critical.
- In depth experience in the automation, process development, optimization, and technology transfer of bioprocesses (involving some aspect of cell culture, if not cell therapy).
- A deep understanding of technologies suitable for T cell isolation, activation, transduction and expansion are key and would need to be developed if not understood initially.
- The ability to be able to critically compare and contrast automation options from a commercial, scientific, quality and regulatory standpoint is key to the success of the role.
- Skill including leadership, communication, project planning, external stakeholder management and critically collaboration.
- Significant experience of working in and leading matrix teams will be required
- Knowledge of T cell biology, adoptive T cell therapy and gene therapy would be an advantage.
- Knowledge of statistical experimental design (such as DoE) or multivariate data analysis would be a significant advantage.
Job type: Permanent
Location: Southwest England
Salary: Negotiable (DOE)
If you are interested in this role or know anyone who might be please get in touch with an up to date CV and I'll be in touch.